SS-31

Research reference

Research on a named molecule describes the published experimental material. It does not verify the contents or performance of this vial.

Identity

SS-31, also called elamipretide in published research, is a mitochondria-targeted tetrapeptide. The salt form of an individual vial must be checked against its lot documentation.

Research focus

Investigators have examined how SS-31 interacts with cardiolipin in the mitochondrial inner membrane and with cytochrome c at that membrane.

Models and measurements

The cited experiments used fluorescent binding measurements, isolated mitochondrial systems and ischemia models. Relevant readouts included cardiolipin binding, cytochrome-c peroxidase activity and mitochondrial bioenergetics.

How to interpret the evidence

Membrane and animal-model findings do not establish the identity or biological effect of a retail vial. Clinical evidence and regulatory status must be evaluated separately.

Selected primary studies

• Birk and colleagues, 2013 ↗Reported cardiolipin binding and altered cytochrome-c peroxidase activity in experimental systems.
• Szeto and colleagues, 2014 ↗Examined cardiolipin and cytochrome-c interactions and mitochondrial electron transfer.

Draft reference identifiers

From supplied draft material, not lot-certified values. Confirm each identifier against a certificate of analysis.

Sequence

D-Arg-Dmt-Lys-Phe-NH2

Mass

733.93 g/mol